Post-translational modifications in nitrile hydratase family
نویسندگان
چکیده
Fe-type nitrile hydratase (NHase) from Rhodococcus sp. N771 has a novel non-heme iron active center with two post-translationally modified cysteine residues, cysteine-sulfenic and -sulfinic acids. The modified residues are involved in the sequence motif, Cys-Xxx-Leu-Cys-Ser-Cys (Xxx = Ser(Fetype)/Thr(Co-type)), which is conserved among all known NHases as well as in the homologous enzyme, thiocyanate hydrolase. Studies on the Fe-type NHase of Rhodococcus sp. N771 have shown that the modifications are indispensable for the catalytic activity. Recent studies on other enzymes in the NHase family are also discussed. M. Odaka
منابع مشابه
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